GPX2

Across TCGA patient cohorts, GPX2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,126 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPX2-associated genes across cancer lineages are ADAM23, PGAP4, and PTCH1. Each is linked with GPX2 in more than 5 cancer types. Because this analysis shows association rather than direction, both GPX2-to-partner and partner-to-GPX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPX2 versus ADAM23 in LSCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX2→partner) and Y-score (partner→GPX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADAM23 →	+2.333	+1.561	<.001	<.001	3	5
LSCC	PGAP4 →	+1.600	+1.783	<.001	<.001	3	5
BRCA	PTCH1 →	+0.993	+0.878	<.001	<.001	3	5
LSCC	ARL4AP3 →	+1.193	+1.335	<.001	<.001	3	5
LSCC	FREM2 →	+1.541	+1.321	<.001	<.001	3	5
HNSC	CYP4F12 →	+1.215	+1.078	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,126 associations by consensus.

GPX2 vs ADAM23 — LSCC

Explore this scatter interactively →