GPX2

Across TCGA patient cohorts, GPX2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX2-associated genes across cancer lineages are p62 Lck ligand, JNK2, and TIGAR. Each is linked with GPX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX2-to-partner and partner-to-GPX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by GPX2-low versus GPX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX2→partner) and Y-score (partner→GPX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.597	+2.817	<.001	.036	3	1
UCEC	JNK2 →	+0.353	+2.817	.001	.036	2	1
UCEC	TIGAR →	+0.172	+3.196	.040	.010	2	1
UCEC	Tuberin →	+0.453	+3.169	.002	.020	2	1
UCEC	Notch1 →	+0.169	+3.169	.028	.020	1	1
UCEC	SF2 →	-0.182	-3.156	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by GPX2 expression — UCEC

Explore this box plot interactively →