GPX1

Across TCGA pan-cancer cohorts, GPX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GPX1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, GBM, and PDAC are the cancer types where GPX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.909	0.994	.005	10	view →
GBM	OS	Tertile	All	0.385	0.621	.006	9	view →
PDAC	OS	Tertile	III,IV	0.296	0.639	.012	8	view →
UCEC	OS	Median	II,III,IV	1.000	0.647	.017	4	view →
CCRCC	DFS	Median	III,IV	0.466	0.670	.040	2	view →
LUAD	OS	Quartile	All	0.451	0.782	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GPX1–HNSC (DFS)

Open the HNSC breakdown →