GPX1

Across TCGA patient cohorts, GPX1 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX1-associated genes across cancer lineages are RN7SL240P, TRBV5-3, and RNU6-1188P. Each is linked with GPX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX1-to-partner and partner-to-GPX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL240P grouped by GPX1-low versus GPX1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX1→partner) and Y-score (partner→GPX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL240P →	+0.129	+7.816	<.001	.008	3	2
COAD	TRBV5-3 →	+0.229	+4.543	.002	.005	3	2
BLCA	RNU6-1188P →	+0.309	+5.411	.006	.005	3	1
BLCA	RNU6-668P →	+0.309	+5.329	.002	.006	3	1
BLCA	SNORD116-12 →	+0.502	+5.497	<.001	.004	3	1
HNSC	MIR96 →	+0.483	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

RN7SL240P by GPX1 expression — SKCM

Explore this box plot interactively →