GPX1

Across TCGA cell cohorts, GPX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,731 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPX1-associated GO terms across cancer lineages are Response to folic acid, Lipoxygenase pathway, and Positive regulation of fibroblast proliferation. Each is linked with GPX1 in more than 9 cancer types. Because this analysis shows association rather than direction, both GPX1-to-partner and partner-to-GPX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to folic acid grouped by GPX1-low versus GPX1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX1→partner) and Y-score (partner→GPX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Response to folic acid →	+0.170	+1.617	<.001	<.001	3	10
BREAST	Lipoxygenase pathway →	+0.289	+3.392	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of fibroblast proliferation →	+0.149	+2.897	<.001	<.001	3	8
SKIN	Response to selenium ion →	+0.147	+1.755	<.001	.001	3	8
BREAST	Positive regulation of early endosome to late endosome transport →	+0.132	+3.504	<.001	.001	3	8
BREAST	Trans-synaptic signaling by BDNF, modulating synaptic transmission →	+0.941	+3.508	.002	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,731 associations by consensus.

Response to folic acid by GPX1 expression — BLOOD_Lymphoma

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