GPT2

Across TCGA patient cohorts, GPT2 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,239 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPT2-associated proteins across cancer lineages are AARS1, PHGDH, and REPIN1. Each is linked with GPT2 in more than 6 cancer types. Because this analysis shows association rather than direction, both GPT2-to-partner and partner-to-GPT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPT2 versus AARS1 in OV, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT2→partner) and Y-score (partner→GPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AARS1 →	+0.365	+0.878	<.001	<.001	3	7
BRCA	PHGDH →	+0.752	+1.067	<.001	<.001	3	6
COAD	REPIN1 →	+0.354	+0.674	.002	.004	3	6
LSCC	HSPD1 →	+0.432	+0.672	<.001	<.001	3	6
UCEC	KANK2 →	-0.538	-0.485	.001	.007	3	6
COAD	LONP2 →	+0.312	+0.730	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,239 associations by consensus.

GPT2 vs AARS1 — OV

Explore this scatter interactively →