GPT2

Across TCGA patient cohorts, GPT2 mutation is significantly associated with the RNA expression of many other genes, with 1,996 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPT2-associated genes across cancer lineages are RNU6-862P, RNU6-1316P, and RNU7-128P. Each is linked with GPT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPT2-to-partner and partner-to-GPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-862P grouped by GPT2-low versus GPT2-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT2→partner) and Y-score (partner→GPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	RNU6-862P →	+0.579	+5.005	<.001	.009	3	3
READ	RNU6-1316P →	+0.404	+4.937	<.001	.002	3	2
READ	RNU7-128P →	+0.597	+4.445	.001	.005	3	2
READ	MIR4297 →	+0.716	+5.804	<.001	<.001	3	2
UCEC	MPPE1 →	+0.681	+2.510	<.001	.001	3	2
UCEC	EME1 →	+0.534	+2.673	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,996 associations by consensus.

RNU6-862P by GPT2 expression — SARC

Explore this box plot interactively →