GPT2

Across TCGA patient cohorts, GPT2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPT2-associated genes across cancer lineages are p62 Lck ligand, IGFBP2, and MSH6. Each is linked with GPT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPT2-to-partner and partner-to-GPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by GPT2-low versus GPT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT2→partner) and Y-score (partner→GPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.393	+3.906	.005	<.001	3	2
UCEC	IGFBP2 →	-0.873	-2.999	.002	.035	3	1
UCEC	MSH6 →	-0.284	-3.169	.048	.018	3	1
UCEC	Notch1 →	+0.172	+2.183	.005	.033	3	1
UCEC	p90 RSK →	+0.172	+2.331	.040	.019	3	1
UCEC	PCNA →	+0.226	+2.999	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

p62 Lck ligand by GPT2 expression — UCEC

Explore this box plot interactively →