GPT2

Across TCGA cell cohorts, GPT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,595 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GPT2-associated GO terms across cancer lineages are L-alanine catabolic process, Proteinogenic amino acid biosynthetic process, and L-amino acid biosynthetic process. Each is linked with GPT2 in more than 18 cancer types. Because this analysis shows association rather than direction, both GPT2-to-partner and partner-to-GPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-alanine catabolic process grouped by GPT2-low versus GPT2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT2→partner) and Y-score (partner→GPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	L-alanine catabolic process →	+1.147	+1.228	<.001	<.001	3	19
LUNG_NSCLC_LUAD	Proteinogenic amino acid biosynthetic process →	+0.137	+1.350	<.001	<.001	3	16
PANCREAS	L-amino acid biosynthetic process →	+0.131	+1.391	.002	<.001	3	15
LUNG_NSCLC_LUAD	Alpha-amino acid biosynthetic process →	+0.112	+1.180	<.001	<.001	3	15
URINARY_TRACT	2-oxoglutarate metabolic process →	+0.176	+1.492	<.001	<.001	3	15
URINARY_TRACT	L-serine metabolic process →	+0.159	+0.958	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,595 associations by consensus.

L-alanine catabolic process by GPT2 expression — SKIN

Explore this box plot interactively →