GPT2

Across TCGA cell cohorts, GPT2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPT2-associated genes across cancer lineages are ACER1, C20orf85, and IL9. Each is linked with GPT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPT2-to-partner and partner-to-GPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by GPT2-low versus GPT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPT2→partner) and Y-score (partner→GPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.071	+3.145	.004	.004	3	1
BLOOD_Leukemia	C20orf85 →	+0.042	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL9 →	+0.148	+4.539	<.001	.007	3	1
BLOOD_Leukemia	LCN1 →	+0.037	+5.507	<.001	<.001	3	1
BLOOD_Leukemia	PRM3 →	+0.067	+5.569	<.001	.001	3	1
BLOOD_Leukemia	GABRR3 →	+0.029	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACER1 by GPT2 expression — LARGE_INTESTINE

Explore this box plot interactively →