Across TCGA pan-cancer cohorts, GPSM3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPSM3 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GPSM3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPSM3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where GPSM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	0.757	1.000	.030	36	view →
PDAC	DFS	Tertile	III,IV	0.542	0.192	.011	18	view →
HNSC	DFS	Median	II,III,IV	0.681	0.891	.002	13	view →
LUAD	OS	Quartile	III,IV	0.347	0.813	.026	5	view →
LSCC	OS	Median	III,IV	0.951	0.758	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: GPSM3 tumor-vs-normal RNA expression · all GPSM3 data types