GPSM2

Across TCGA patient cohorts, GPSM2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPSM2-associated genes across cancer lineages are ATM, ASNS, and 4E-BP1_pT70. Each is linked with GPSM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPSM2-to-partner and partner-to-GPSM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GPSM2-low versus GPSM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPSM2→partner) and Y-score (partner→GPSM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.467	-2.321	.004	.001	3	4
COAD	ASNS →	+0.799	+3.008	<.001	.019	3	2
COAD	4E-BP1_pT70 →	+0.147	+3.008	.017	.019	1	4
COAD	c-Myc →	-0.243	-2.991	.047	.036	3	2
UCEC	PDCD4 →	-0.554	-2.459	.001	.018	3	2
UCEC	4E-BP1 →	+0.271	+3.321	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ATM by GPSM2 expression — UCEC

Explore this box plot interactively →