GPSM2

Across TCGA cell cohorts, GPSM2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPSM2-associated genes across cancer lineages are MTRNR2L6, ASZ1, and OR10R2. Each is linked with GPSM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPSM2-to-partner and partner-to-GPSM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L6 grouped by GPSM2-low versus GPSM2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPSM2→partner) and Y-score (partner→GPSM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.130	+4.357	<.001	.006	3	2
BLOOD_Leukemia	ASZ1 →	+0.132	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR10R2 →	+1.907	+4.551	<.001	.004	3	1
BLOOD_Leukemia	TSSK1B →	+0.014	+4.874	<.001	.002	3	1
LARGE_INTESTINE	USP29 →	+0.014	+4.415	<.001	.007	3	1
SKIN	OR1E3 →	+0.036	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MTRNR2L6 by GPSM2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →