GPSM1

Across TCGA patient cohorts, GPSM1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPSM1-associated genes across cancer lineages are PCNA, Annexin-1, and Caspase-7-cleavedD198. Each is linked with GPSM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPSM1-to-partner and partner-to-GPSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by GPSM1-low versus GPSM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPSM1→partner) and Y-score (partner→GPSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.404	+2.815	.002	.036	3	2
UCEC	Annexin-1 →	+0.847	+2.720	<.001	.003	3	2
COAD	Caspase-7-cleavedD198 →	+1.598	+2.815	<.001	.036	2	3
UCEC	EGFR_pY1068 →	-0.277	-2.000	.004	.029	3	2
UCEC	p62 Lck ligand →	+0.324	+2.125	.011	.010	3	2
COAD	PREX1 →	+0.358	+2.832	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PCNA by GPSM1 expression — COAD

Explore this box plot interactively →