GPS1

Across TCGA pan-cancer cohorts, GPS1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GPS1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GPS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPS1 expression acts as an unfavorable survival marker.

CESC and PCPG are the cancer types where GPS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.095	0.755	<.001	18	view →
PCPG	DFS	Median	All	0.135	0.770	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GPS1–CESC (OS)

Open the CESC breakdown →