GPS1

Across TCGA pan-cancer cohorts, GPS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GPS1 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GPS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GPS1 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, LUAD, and GBM are the cancer types where GPS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.907	.008	54	view →
LUAD	DFS	Median	III,IV	0.247	0.805	.001	26	view →
GBM	OS	Tertile	All	0.255	0.497	.018	10	view →
PDAC	DFS	Median	II,III,IV	0.317	0.509	.023	10	view →
CCRCC	OS	Median	III,IV	0.962	0.806	.039	2	view →
LSCC	OS	Tertile	II,III,IV	0.945	0.674	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GPS1–COAD (DFS)

Open the COAD breakdown →