GPS1

Across TCGA patient cohorts, GPS1 mutation is significantly associated with the RNA expression of many other genes, with 1,357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPS1-associated genes across cancer lineages are IGLVI-38, MIR7-3, and NMNAT1P1. Each is linked with GPS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPS1-to-partner and partner-to-GPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGLVI-38 grouped by GPS1-low versus GPS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPS1→partner) and Y-score (partner→GPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGLVI-38 →	+0.090	+1.898	.001	.009	3	3
CESC	MIR7-3 →	+0.179	+4.342	<.001	.007	3	2
BLCA	NMNAT1P1 →	+0.093	+4.588	<.001	.008	3	2
COAD	IGKV2-36 →	+0.236	+5.332	<.001	.002	3	2
UCEC	PTP4A2P1 →	+0.476	+2.931	<.001	<.001	3	2
UCEC	FBXO7 →	+0.332	+2.021	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,357 associations by consensus.

IGLVI-38 by GPS1 expression — UCEC

Explore this box plot interactively →