GPS1

Across TCGA cell cohorts, GPS1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPS1-associated genes across cancer lineages are KRT6C, PHOX2B, and GSC. Each is linked with GPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPS1-to-partner and partner-to-GPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT6C grouped by GPS1-low versus GPS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPS1→partner) and Y-score (partner→GPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRT6C →	+0.016	+3.359	<.001	.002	3	2
BLOOD_Leukemia	PHOX2B →	+0.017	+3.365	<.001	.005	3	1
BLOOD_Leukemia	GSC →	+0.713	+4.211	.007	<.001	3	1
BLOOD_Leukemia	MYOM3 →	+0.058	+4.106	<.001	.003	3	1
BLOOD_Leukemia	LRRC38 →	+1.731	+3.631	<.001	.006	3	1
BLOOD_Leukemia	TACR3 →	+0.025	+3.890	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

KRT6C by GPS1 expression — BLOOD_Leukemia

Explore this box plot interactively →