Across TCGA pan-cancer cohorts, GPRIN3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GPRIN3 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GPRIN3 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GPRIN3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LUAD, and LUSC are the cancer types where GPRIN3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.965	0.611	.005	28	view →
LUAD	DFS	Median	All	0.293	0.684	<.001	28	view →
LUSC	OS	Median	III,IV	0.006	0.674	<.001	22	view →
SKCM	DFS	Median	All	0.804	0.210	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: GPRIN3 tumor-vs-normal RNA expression · all GPRIN3 data types