GPRIN1

Across TCGA patient cohorts, GPRIN1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPRIN1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Rad50, and ATM. Each is linked with GPRIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRIN1-to-partner and partner-to-GPRIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by GPRIN1-low versus GPRIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRIN1→partner) and Y-score (partner→GPRIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.351	-1.700	.030	.042	3	2
UCEC	Rad50 →	-0.195	-1.584	.025	.019	3	2
UCEC	ATM →	-0.633	-2.571	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.238	-1.584	.008	.019	3	1
UCEC	EGFR_pY1173 →	+0.064	+1.306	.025	.036	3	1
UCEC	eIF4E →	+0.165	+3.183	.030	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p38-MAPK_pT180_Y182 by GPRIN1 expression — UCEC

Explore this box plot interactively →