GPRIN1

Across TCGA cell cohorts, GPRIN1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GPRIN1-associated genes across cancer lineages are OR4X2, KLK9, and OR12D2. Each is linked with GPRIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRIN1-to-partner and partner-to-GPRIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by GPRIN1-low versus GPRIN1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRIN1→partner) and Y-score (partner→GPRIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4X2 →	+0.031	+4.981	<.001	.008	3	1
CNS	KLK9 →	+0.683	+6.357	<.001	<.001	3	1
CNS	OR12D2 →	+0.015	+4.981	<.001	.008	3	1
LUNG_NSCLC_LUAD	OCSTAMP →	+0.009	+3.343	.002	.005	3	1
LUNG_NSCLC_LUAD	COX6A2 →	+0.540	+4.299	.005	.001	3	1
LUNG_NSCLC_LUAD	ZNF729 →	+0.248	+3.481	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR4X2 by GPRIN1 expression — CNS

Explore this box plot interactively →