GPRC6A

Across TCGA patient cohorts, GPRC6A mutation is significantly associated with the RNA expression of many other genes, with 5,914 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GPRC6A-associated genes across cancer lineages are AATF, RNU6-768P, and DLAT. Each is linked with GPRC6A in more than 2 cancer types. Because this analysis shows association rather than direction, both GPRC6A-to-partner and partner-to-GPRC6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AATF grouped by GPRC6A-low versus GPRC6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC6A→partner) and Y-score (partner→GPRC6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AATF →	+0.324	+1.678	.001	<.001	3	3
BLCA	RNU6-768P →	+0.742	+4.492	<.001	.005	3	3
UCEC	DLAT →	+0.431	+1.678	.001	<.001	3	3
SKCM	CENPU →	+0.579	+1.478	<.001	<.001	3	3
UCEC	SKA1 →	+0.636	+3.269	<.001	<.001	3	3
UCEC	EME1 →	+0.466	+1.688	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,914 associations by consensus.

AATF by GPRC6A expression — UCEC

Explore this box plot interactively →