GPRC6A

Across TCGA patient cohorts, GPRC6A mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPRC6A-associated genes across cancer lineages are Cyclin-B1, Gab2, and MEK1. Each is linked with GPRC6A in more than 3 cancer types. Because this analysis shows association rather than direction, both GPRC6A-to-partner and partner-to-GPRC6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by GPRC6A-low versus GPRC6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC6A→partner) and Y-score (partner→GPRC6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.651	+2.662	<.001	<.001	3	4
UCEC	Gab2 →	+0.232	+1.700	.029	.040	3	3
UCEC	MEK1 →	+0.396	+2.050	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.643	+1.534	<.001	.008	3	3
LUAD	Bim →	+0.274	+2.321	.040	.035	3	2
UCEC	14-3-3_beta →	-0.104	-1.794	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Cyclin-B1 by GPRC6A expression — UCEC

Explore this box plot interactively →