GPRC6A

Across TCGA cell cohorts, GPRC6A mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPRC6A-associated genes across cancer lineages are ECRG4, OR11H1, and CD8B. Each is linked with GPRC6A in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRC6A-to-partner and partner-to-GPRC6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECRG4 grouped by GPRC6A-low versus GPRC6A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC6A→partner) and Y-score (partner→GPRC6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ECRG4 →	+0.062	+3.188	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR11H1 →	+0.013	+3.201	.005	.004	3	1
LUNG_NSCLC_LUAD	CD8B →	+0.247	+3.196	<.001	.003	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.010	+3.944	<.001	.006	3	1
LUNG_SCLC	SLC25A31 →	+0.030	+3.070	<.001	<.001	3	1
LUNG_SCLC	CD28 →	+0.086	+3.125	.002	.008	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

ECRG4 by GPRC6A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →