GPRC5D

Across TCGA pan-cancer cohorts, GPRC5D Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GPRC5D data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GPRC5D Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPRC5D expression acts as an unfavorable survival marker.

BLCA and LUAD are the cancer types where GPRC5D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.247	0.620	.015	12	view →
LUAD	OS	Median	All	0.176	0.835	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GPRC5D–BLCA (OS)

Open the BLCA breakdown →