GPRC5D

Across TCGA pan-cancer cohorts, GPRC5D mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GPRC5D data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GPRC5D mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GPRC5D expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where GPRC5D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.768	1.000	.011	30	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	10	view →
UCEC	DFS	Quartile	All	0.699	0.964	.012	8	view →
LUAD	OS	Median	III,IV	0.750	0.998	.025	5	view →
HNSC	DFS	Quartile	III,IV	0.719	0.510	.044	1	view →
GBM	OS	Quartile	All	0.824	0.934	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GPRC5D–CCRCC (OS)

Open the CCRCC breakdown →