GPRC5B

Across TCGA pan-cancer cohorts, GPRC5B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GPRC5B data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GPRC5B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GPRC5B expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

PDAC, GBM, and UCEC are the cancer types where GPRC5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.386	1.000	.038	12	view →
GBM	DFS	Quartile	All	0.562	0.255	.009	7	view →
UCEC	OS	Median	All	1.000	0.909	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GPRC5B–PDAC (OS)

Open the PDAC breakdown →