GPRC5B

Across TCGA cell cohorts, GPRC5B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,454 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GPRC5B-associated GO terms across cancer lineages are Negative regulation of cell-substrate adhesion, Cellular component disassembly, and Substrate adhesion-dependent cell spreading. Each is linked with GPRC5B in more than 8 cancer types. Because this analysis shows association rather than direction, both GPRC5B-to-partner and partner-to-GPRC5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell-substrate adhesion grouped by GPRC5B-low versus GPRC5B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5B→partner) and Y-score (partner→GPRC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of cell-substrate adhesion →	+0.109	+3.362	.003	.001	3	8
STOMACH	Cellular component disassembly →	+0.042	+1.520	.005	.009	2	9
LARGE_INTESTINE	Substrate adhesion-dependent cell spreading →	+0.119	+1.475	<.001	<.001	3	8
BREAST	Potassium ion transmembrane transport →	-0.047	-1.238	.002	.004	3	8
BREAST	Negative regulation of transforming growth factor beta production →	+0.254	+1.997	.001	<.001	3	8
OESOPHAGUS	Regulation of myoblast fusion →	+0.120	+1.569	.003	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,454 associations by consensus.

Negative regulation of cell-substrate adhesion by GPRC5B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →