GPRC5B

Across TCGA cell cohorts, GPRC5B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPRC5B-associated genes across cancer lineages are NAT8, REG3A, and REG1B. Each is linked with GPRC5B in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRC5B-to-partner and partner-to-GPRC5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAT8 grouped by GPRC5B-low versus GPRC5B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5B→partner) and Y-score (partner→GPRC5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NAT8 →	+0.575	+3.706	.001	.002	3	1
LARGE_INTESTINE	REG3A →	+1.816	+3.584	.001	.003	3	1
LARGE_INTESTINE	REG1B →	+2.942	+2.933	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
LARGE_INTESTINE	SMIM33 →	+0.822	+3.648	<.001	.002	3	1
LARGE_INTESTINE	GSC2 →	+0.086	+2.688	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NAT8 by GPRC5B expression — LARGE_INTESTINE

Explore this box plot interactively →