GPRC5A

Across TCGA pan-cancer cohorts, GPRC5A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GPRC5A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GPRC5A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GPRC5A is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

COAD, CCRCC, and PDAC are the cancer types where GPRC5A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPRC5A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+2.169	<.001	12	view →
CCRCC	Male	III,IV	−1.863	<.001	12	view →
PDAC	All	III,IV	+1.628	<.001	10	view →
LUAD	Female	III,IV	−1.972	<.001	9	view →
LSCC	Male	II,III,IV	−2.289	<.001	8	view →
HNSC	Male	III,IV	+0.635	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GPRC5A–COAD

Open the COAD breakdown →