GPRC5A

Across TCGA patient cohorts, GPRC5A mutation is significantly associated with the RNA expression of many other genes, with 3,849 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPRC5A-associated genes across cancer lineages are DCP1A, ZNHIT3, and RNA5SP412. Each is linked with GPRC5A in more than 1 cancer types. Because this analysis shows association rather than direction, both GPRC5A-to-partner and partner-to-GPRC5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCP1A grouped by GPRC5A-low versus GPRC5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPRC5A→partner) and Y-score (partner→GPRC5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCP1A →	+0.634	+3.115	<.001	<.001	3	2
UCEC	ZNHIT3 →	+0.445	+2.665	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.592	+2.041	<.001	<.001	3	2
CESC	LINC02485 →	+0.171	+4.234	<.001	.003	3	2
CESC	LINC02378 →	+0.044	+4.345	<.001	.002	3	2
CESC	SNRPGP6 →	+0.127	+5.252	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,849 associations by consensus.

DCP1A by GPRC5A expression — UCEC

Explore this box plot interactively →