GPR89A

Across TCGA patient cohorts, GPR89A mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR89A-associated genes across cancer lineages are FOXO3a_pS318_S321, INPP4B, and Ku80. Each is linked with GPR89A in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR89A-to-partner and partner-to-GPR89A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by GPR89A-low versus GPR89A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR89A→partner) and Y-score (partner→GPR89A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.150	-3.160	.022	.019	3	1
UCEC	INPP4B →	-0.404	-3.308	.017	.010	3	1
UCEC	Ku80 →	+0.259	+2.183	.036	.035	3	1
UCEC	MEK1_p_S217_S221 →	-0.311	-3.321	.029	.010	3	1
UCEC	p70-S6K →	+0.228	+2.196	.023	.034	3	1
UCEC	AMPK_alpha →	-0.210	-3.169	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FOXO3a_pS318_S321 by GPR89A expression — UCEC

Explore this box plot interactively →