GPR89A

Across TCGA cell cohorts, GPR89A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,305 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR89A-associated GO terms across cancer lineages are Intracellular pH reduction, Regulation of RNA export from nucleus, and Regulation of centrosome cycle. Each is linked with GPR89A in more than 11 cancer types. Because this analysis shows association rather than direction, both GPR89A-to-partner and partner-to-GPR89A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular pH reduction grouped by GPR89A-low versus GPR89A-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR89A→partner) and Y-score (partner→GPR89A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Intracellular pH reduction →	+0.076	+0.681	<.001	<.001	3	12
SOFT_TISSUE	Regulation of RNA export from nucleus →	+0.095	+0.649	.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of centrosome cycle →	+0.092	+0.797	<.001	<.001	3	11
BLOOD_Myeloma	mRNA 3'-end processing →	+0.097	+1.009	<.001	.003	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.070	+0.635	.005	.007	2	11
SOFT_TISSUE	Positive regulation of mRNA processing →	+0.114	+0.539	.004	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,305 associations by consensus.

Intracellular pH reduction by GPR89A expression — SKIN

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