GPR88

Across TCGA patient cohorts, GPR88 mutation is significantly associated with the RNA expression of many other genes, with 2,380 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR88-associated genes across cancer lineages are RNY4P23, RNU6-1245P, and PHF7. Each is linked with GPR88 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR88-to-partner and partner-to-GPR88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P23 grouped by GPR88-low versus GPR88-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR88→partner) and Y-score (partner→GPR88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNY4P23 →	+0.422	+6.479	<.001	.001	3	2
LIHC	RNU6-1245P →	+0.359	+6.008	<.001	.002	3	2
COAD	PHF7 →	+0.661	+3.183	<.001	.009	3	2
UCEC	DCTN6 →	+0.536	+2.233	.002	.006	3	2
UCEC	KCTD9 →	+0.916	+3.606	<.001	.001	3	2
COAD	TLE6 →	+0.482	+3.489	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,380 associations by consensus.

RNY4P23 by GPR88 expression — LIHC

Explore this box plot interactively →