GPR85

Across TCGA cell cohorts, GPR85 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR85-associated genes across cancer lineages are AVP, G6PC2, and SIGLEC11. Each is linked with GPR85 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR85-to-partner and partner-to-GPR85 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by GPR85-low versus GPR85-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR85→partner) and Y-score (partner→GPR85) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.041	+3.217	<.001	.006	3	1
LARGE_INTESTINE	G6PC2 →	+0.039	+3.921	<.001	.001	3	1
LARGE_INTESTINE	SIGLEC11 →	+0.025	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	ELOA3DP →	+0.022	+3.103	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
BREAST	LCN9 →	+0.070	+5.754	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

AVP by GPR85 expression — LARGE_INTESTINE

Explore this box plot interactively →