GPR78

Across TCGA pan-cancer cohorts, GPR78 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GPR78 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GPR78 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR78 expression acts as an unfavorable survival marker.

KIRC, LUSC, and READ are the cancer types where GPR78 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	IV	0.205	0.603	.001	30	view →
LUSC	OS	Median	II,III,IV	0.114	0.736	<.001	22	view →
READ	DFS	Median	All	0.082	0.845	<.001	18	view →
LUAD	OS	Median	II,III,IV	0.090	0.677	<.001	18	view →
OV	DFS	Median	II,III,IV	0.204	0.541	.017	12	view →
HNSC	DFS	Median	IV	0.122	0.670	.008	9	view →
UVM	OS	Median	All	0.315	0.711	.049	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GPR78–KIRC (DFS)

Open the KIRC breakdown →