GPR78

Across TCGA patient cohorts, GPR78 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR78-associated genes across cancer lineages are MAPK_pT202_Y204, MEK1, and Annexin-1. Each is linked with GPR78 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR78-to-partner and partner-to-GPR78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by GPR78-low versus GPR78-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR78→partner) and Y-score (partner→GPR78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.593	-3.000	.015	.036	3	1
UCEC	MEK1 →	+0.586	+3.321	.002	.010	3	1
UCEC	Annexin-1 →	+0.960	+2.189	<.001	.034	3	1
UCEC	VHL →	-1.130	-3.000	.001	.036	3	1
UCEC	ATM →	-0.693	-3.321	.003	.010	3	1
UCEC	C-Raf_pS338 →	-0.130	-2.950	.002	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MAPK_pT202_Y204 by GPR78 expression — UCEC

Explore this box plot interactively →