GPR78

Across TCGA cell cohorts, GPR78 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,456 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible GPR78-associated GO terms across cancer lineages are Cellular response to steroid hormone stimulus, Endosomal transport, and Regulation of intrinsic apoptotic signaling pathway. Each is linked with GPR78 in more than 8 cancer types. Because this analysis shows association rather than direction, both GPR78-to-partner and partner-to-GPR78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to steroid hormone stimulus grouped by GPR78-low versus GPR78-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR78→partner) and Y-score (partner→GPR78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Cellular response to steroid hormone stimulus →	+0.049	+2.409	.007	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.059	+1.103	.008	.009	3	9
URINARY_TRACT	Regulation of intrinsic apoptotic signaling pathway →	+0.048	+2.106	<.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Actin filament organization →	+0.066	+0.745	.001	.006	3	8
UPPER_AERODIGESTIVE_TRACT	Viral process →	+0.063	+0.775	<.001	.001	3	8
LUNG_NSCLC_LUSC	Response to acid chemical →	+0.049	+0.349	.002	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,456 associations by consensus.

Cellular response to steroid hormone stimulus by GPR78 expression — URINARY_TRACT

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