GPR75

Across TCGA patient cohorts, GPR75 protein abundance is significantly associated with the RNA expression of many other genes, with 230 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GPR75-associated genes across cancer lineages are MGRN1, CAPN15, and PLPPR2. Each is linked with GPR75 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR75-to-partner and partner-to-GPR75 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR75 versus MGRN1 in GBM, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR75→partner) and Y-score (partner→GPR75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MGRN1 →	+0.495	+0.867	.004	.007	3	1
GBM	CAPN15 →	+0.484	+0.956	.007	.002	3	1
GBM	PLPPR2 →	+0.809	+1.036	<.001	<.001	3	1
GBM	RAI1 →	+0.768	+0.921	.004	.003	3	1
GBM	CCL8 →	-2.050	-1.328	.002	<.001	3	1
GBM	HPX →	+0.516	+1.001	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 230 associations by consensus.

GPR75 vs MGRN1 — GBM

Explore this scatter interactively →