GPR75

Across TCGA patient cohorts, GPR75 mutation is significantly associated with the RNA expression of many other genes, with 1,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR75-associated genes across cancer lineages are MIR4769, RNA5SP411, and MIR509-3. Each is linked with GPR75 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR75-to-partner and partner-to-GPR75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4769 grouped by GPR75-low versus GPR75-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR75→partner) and Y-score (partner→GPR75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4769 →	+0.213	+2.635	<.001	.004	3	3
LUSC	RNA5SP411 →	+0.860	+5.733	<.001	.001	3	3
UCEC	MIR509-3 →	+0.310	+2.379	<.001	.008	3	3
SKCM	PRAMEF34P →	+0.009	+5.816	<.001	<.001	3	2
UCEC	AUP1 →	+0.254	+2.353	.002	.003	3	2
UCEC	CD2 →	+0.944	+2.403	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,213 associations by consensus.

MIR4769 by GPR75 expression — UCEC

Explore this box plot interactively →