GPR75

Across TCGA cell cohorts, GPR75 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,510 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GPR75-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Regulation of mRNA splicing, via spliceosome, and RNA localization. Each is linked with GPR75 in more than 17 cancer types. Because this analysis shows association rather than direction, both GPR75-to-partner and partner-to-GPR75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by GPR75-low versus GPR75-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR75→partner) and Y-score (partner→GPR75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.174	+0.928	<.001	<.001	3	18
BONE	Regulation of mRNA splicing, via spliceosome →	+0.116	+1.073	<.001	<.001	3	18
OESOPHAGUS	RNA localization →	+0.134	+0.917	<.001	.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of telomerase RNA localization to Cajal body →	+0.110	+0.760	<.001	<.001	3	17
STOMACH	Epigenetic regulation of gene expression →	+0.081	+0.939	<.001	.001	3	17
SOFT_TISSUE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.155	+0.999	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,510 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by GPR75 expression — BONE

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