GPR75

Across TCGA cell cohorts, GPR75 mutation is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR75-associated genes across cancer lineages are USP17L8, PRSS58, and EDDM3A. Each is linked with GPR75 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR75-to-partner and partner-to-GPR75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L8 grouped by GPR75-low versus GPR75-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR75→partner) and Y-score (partner→GPR75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	USP17L8 →	+0.013	+5.977	<.001	.001	3	1
SOFT_TISSUE	PRSS58 →	+0.205	+4.930	<.001	.008	3	1
SKIN	EDDM3A →	+0.022	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	PRLH →	+0.222	+5.228	<.001	.005	3	1
LARGE_INTESTINE	GCAT →	+1.267	+3.212	.002	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.657	+3.299	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

USP17L8 by GPR75 expression — SOFT_TISSUE

Explore this box plot interactively →