GPR65

Across TCGA patient cohorts, GPR65 protein abundance is significantly associated with the RNA expression of many other genes, with 459 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GPR65-associated genes across cancer lineages are PRKAR2B, RSPH6A, and ARAP3. Each is linked with GPR65 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR65-to-partner and partner-to-GPR65 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR65 versus PRKAR2B in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR65→partner) and Y-score (partner→GPR65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKAR2B →	-1.924	-0.643	.009	.009	3	2
UCEC	RSPH6A →	+0.585	+0.717	<.001	.006	3	1
UCEC	ARAP3 →	+0.953	+0.586	.001	.002	3	1
UCEC	CPA6 →	+1.904	+0.609	.006	.009	3	1
UCEC	SMCO3 →	-0.406	-0.586	<.001	.002	3	1
UCEC	IL6-AS1 →	-0.338	-0.546	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 459 associations by consensus.

GPR65 vs PRKAR2B — BRCA

Explore this scatter interactively →