GPR63

Across TCGA patient cohorts, GPR63 mutation is significantly associated with the RNA expression of many other genes, with 2,198 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR63-associated genes across cancer lineages are MIR8082, MIR3160-1, and CBL. Each is linked with GPR63 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR63-to-partner and partner-to-GPR63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8082 grouped by GPR63-low versus GPR63-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR63→partner) and Y-score (partner→GPR63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR8082 →	+0.272	+1.976	.001	.007	3	3
LUAD	MIR3160-1 →	+0.274	+3.975	<.001	.002	3	3
LUSC	CBL →	+0.547	+2.854	<.001	.001	3	3
UCEC	SPOP →	+0.387	+3.754	.004	<.001	3	3
UCEC	DNAJC7 →	+0.468	+2.543	<.001	<.001	3	3
UCEC	PICALM →	+0.391	+2.364	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,198 associations by consensus.

MIR8082 by GPR63 expression — UCEC

Explore this box plot interactively →