GPR63

Across TCGA cell cohorts, GPR63 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR63-associated genes across cancer lineages are OR10D3, ECSCR, and OR8D2. Each is linked with GPR63 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR63-to-partner and partner-to-GPR63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10D3 grouped by GPR63-low versus GPR63-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR63→partner) and Y-score (partner→GPR63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10D3 →	+0.010	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ECSCR →	+0.153	+3.777	<.001	.007	3	1
LARGE_INTESTINE	OR8D2 →	+0.040	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	DRD5 →	+0.481	+4.343	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRTAP4-4 →	+0.016	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	LORICRIN →	+0.023	+4.813	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR10D3 by GPR63 expression — LARGE_INTESTINE

Explore this box plot interactively →