GPR6

Across TCGA pan-cancer cohorts, GPR6 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GPR6 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher GPR6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR6 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

PRAD, ACC, and SKCM are the cancer types where GPR6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.111	0.774	<.001	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
SKCM	DFS	Median	II,III,IV	1.000	0.220	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GPR6–PRAD (DFS)

Open the PRAD breakdown →