GPR6

Across TCGA patient cohorts, GPR6 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR6-associated genes across cancer lineages are GSK-3a-b_pS21_S9, C-Raf, and Caspase-7-cleavedD198. Each is linked with GPR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR6-to-partner and partner-to-GPR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by GPR6-low versus GPR6-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR6→partner) and Y-score (partner→GPR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GSK-3a-b_pS21_S9 →	-0.415	-3.169	.013	.019	3	3
STAD	C-Raf →	+0.201	+3.169	.010	.019	3	3
UCEC	Caspase-7-cleavedD198 →	+0.769	+1.827	<.001	.015	3	3
STAD	FASN →	+0.418	+2.823	.041	.034	3	2
UCEC	A-Raf_pS299 →	-0.161	-2.584	<.001	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.162	-2.321	.010	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

GSK-3a-b_pS21_S9 by GPR6 expression — STAD

Explore this box plot interactively →