GPR6

Across TCGA cell cohorts, GPR6 RNA expression is significantly associated with the go_rna of many other GO terms, with 914 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GPR6-associated GO terms across cancer lineages are Cell adhesion mediated by integrin, Bone growth, and Vascular endothelial growth factor production. Each is linked with GPR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR6-to-partner and partner-to-GPR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell adhesion mediated by integrin grouped by GPR6-low versus GPR6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR6→partner) and Y-score (partner→GPR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cell adhesion mediated by integrin →	-0.140	-1.210	.001	<.001	3	3
LUNG_SCLC	Bone growth →	-0.110	-1.093	<.001	.002	3	2
LUNG_SCLC	Vascular endothelial growth factor production →	+0.253	+1.059	.001	<.001	3	2
LUNG_SCLC	Bicarbonate transport →	-0.101	-1.333	<.001	<.001	3	2
LUNG_SCLC	Negative regulation of angiogenesis →	-0.042	-1.010	.001	.002	3	2
LUNG_SCLC	Endoderm formation →	-0.110	-0.976	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 914 associations by consensus.

Cell adhesion mediated by integrin by GPR6 expression — LUNG_SCLC

Explore this box plot interactively →