GPR6

Across TCGA cell cohorts, GPR6 mutation is significantly associated with the drug of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR6-associated genes across cancer lineages are Nutlin-3a (-), GSK1904529A, and AZD5153. Each is linked with GPR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR6-to-partner and partner-to-GPR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by GPR6-low versus GPR6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR6→partner) and Y-score (partner→GPR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+0.769	+2.646	.036	.047	3	1
LARGE_INTESTINE	GSK1904529A →	+0.353	+2.769	.035	.040	3	1
LARGE_INTESTINE	AZD5153 →	+0.561	+2.649	.026	.046	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.455	+2.649	.021	.046	3	1
LARGE_INTESTINE	Sabutoclax →	+0.558	+2.769	.007	.040	3	1
LARGE_INTESTINE	CP724714 →	+0.486	+2.652	.003	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Nutlin-3a (-) by GPR6 expression — LARGE_INTESTINE

Explore this box plot interactively →