GPR55

Across TCGA patient cohorts, GPR55 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR55-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and p62 Lck ligand. Each is linked with GPR55 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR55-to-partner and partner-to-GPR55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by GPR55-low versus GPR55-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR55→partner) and Y-score (partner→GPR55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.170	-1.986	.025	.032	3	1
UCEC	MEK1 →	+0.386	+2.459	.019	.018	3	1
UCEC	p62 Lck ligand →	+0.319	+3.009	.030	.019	3	1
UCEC	STAT3_pY705 →	-0.377	-2.321	.001	.033	3	1
UCEC	TIGAR →	+0.148	+2.026	.031	.018	3	1
UCEC	Bcl-2 →	-0.366	-2.999	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

JNK_pT183_Y185 by GPR55 expression — UCEC

Explore this box plot interactively →